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pentobarbital will lower the extent or effect of zolpidem by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Not known.pentobarbital will minimize the extent or impact of naloxegol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with solid CYP3A4 inducers just isn't proposedpen